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Search Results for " sterol 14-alpha demethylase "

Targets Recommended: Antifection Antifungal

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T0120	Voriconazole UK-109496,伏立康唑	Antifection; Antifungal	Microbiology/Virology
	Voriconazole (UK-109496) 是一种三唑类抗真菌剂，可抑制真菌麦角甾醇的生物合成。它特异性抑制由真菌细胞色素 P450 酶介导的 14-α-羊毛甾醇去甲基化作用
T23174	Posaconazole hydrate	Others	Others
	Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole is a sterol C14ɑ demethylase inhibitor (IC50: 0.25 nM). Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme.
T15708	Lanoconazole	Antifungal	Microbiology/Virology
	Lanoconazole is an orally active imidazole antifungal agent that displays a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis.
TMIH-0604	Voriconazole-d3
	Voriconazole-d3 是 Voriconazole 的氘代化合物。Voriconazole 的 CAS 号为 137234-62-9。Voriconazole 是一种三唑类抗真菌剂，可抑制真菌麦角甾醇的生物合成。它特异性抑制由真菌细胞色素 P450 酶介导的 14-α-羊毛甾醇去甲基化作用
T60853	(Z)-Lanoconazole
	(Z)-Lanoconazole 是 Lanoconazole 的 Z 构型，用于研究皮肤癣菌病和甲癣。Lanoconazole 抑制甾醇 14-α脱甲基酶并阻断真菌膜上的麦角甾醇生物合成，从而干扰麦角甾醇的生物合成。Lanoconazole 是具有口服活性的咪唑类抗真菌剂，在体外和体内均具有广谱的抗真菌活性。

化合物

Voriconazole

Cat.No: T0120

Synonym: UK-109496,伏立康唑

Target: Antifection, Antifungal

Target: Antifungal

Voriconazole-d3

Cat.No: TMIH-0604

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03017	CYP51 Protein, Mycobacterium tuberculosis, Recombinant (His & Myc) Cytochrome P450-14DM,Sterol 14	Mycobacterium tuberculosis	Baculovirus Insect Cells
	Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.